The Yara Gambirasio case: Combining evidence in a complex DNA mixture case

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Standard

The Yara Gambirasio case : Combining evidence in a complex DNA mixture case. / Graversen, Therese; Mortera, Julia; Lago, Giampietro.

I: Forensic Science International: Genetics, Bind 40, 2019, s. 52-63.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Graversen, T, Mortera, J & Lago, G 2019, 'The Yara Gambirasio case: Combining evidence in a complex DNA mixture case', Forensic Science International: Genetics, bind 40, s. 52-63. https://doi.org/10.1016/j.fsigen.2018.12.010

APA

Graversen, T., Mortera, J., & Lago, G. (2019). The Yara Gambirasio case: Combining evidence in a complex DNA mixture case. Forensic Science International: Genetics, 40, 52-63. https://doi.org/10.1016/j.fsigen.2018.12.010

Vancouver

Graversen T, Mortera J, Lago G. The Yara Gambirasio case: Combining evidence in a complex DNA mixture case. Forensic Science International: Genetics. 2019;40:52-63. https://doi.org/10.1016/j.fsigen.2018.12.010

Author

Graversen, Therese ; Mortera, Julia ; Lago, Giampietro. / The Yara Gambirasio case : Combining evidence in a complex DNA mixture case. I: Forensic Science International: Genetics. 2019 ; Bind 40. s. 52-63.

Bibtex

@article{8577a7e678db49e7bb03e28c8a4c96b2,
title = "The Yara Gambirasio case: Combining evidence in a complex DNA mixture case",
abstract = "Here, we illustrate how statistical methods can help extract information from mixed DNA profiles pertaining to an Italian case, referred to by the media as The murder of Yara Gambirasio. We base the analysis on a model for DNA mixtures that takes fully into account the peak heights and possible artefacts, like stutter and dropout that might occur in the DNA amplification process. We show how to combine the evidence from multiple samples and from different marker systems all within the model framework. The combined evidence is used for deconvolution, where the focus is to find likely profiles for the donors to the sample. We also show how a mixture can be used to establish familial relationships between a reference profile and a donor to the mixed DNA sample. We compare results based on a single mixed DNA profile, combination of replicates, combinations of different samples and combinations of different kits. Based on the Yara case, we discuss just a few of the plethora of possibilities of combining evidential information.",
keywords = "Combining evidence, DNA mixtures, Forensic statistics, Kinship, Likelihood ratio, Mixture deconvolution, Probabilistic genotyping",
author = "Therese Graversen and Julia Mortera and Giampietro Lago",
year = "2019",
doi = "10.1016/j.fsigen.2018.12.010",
language = "English",
volume = "40",
pages = "52--63",
journal = "Forensic Science International: Genetics",
issn = "1872-4973",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The Yara Gambirasio case

T2 - Combining evidence in a complex DNA mixture case

AU - Graversen, Therese

AU - Mortera, Julia

AU - Lago, Giampietro

PY - 2019

Y1 - 2019

N2 - Here, we illustrate how statistical methods can help extract information from mixed DNA profiles pertaining to an Italian case, referred to by the media as The murder of Yara Gambirasio. We base the analysis on a model for DNA mixtures that takes fully into account the peak heights and possible artefacts, like stutter and dropout that might occur in the DNA amplification process. We show how to combine the evidence from multiple samples and from different marker systems all within the model framework. The combined evidence is used for deconvolution, where the focus is to find likely profiles for the donors to the sample. We also show how a mixture can be used to establish familial relationships between a reference profile and a donor to the mixed DNA sample. We compare results based on a single mixed DNA profile, combination of replicates, combinations of different samples and combinations of different kits. Based on the Yara case, we discuss just a few of the plethora of possibilities of combining evidential information.

AB - Here, we illustrate how statistical methods can help extract information from mixed DNA profiles pertaining to an Italian case, referred to by the media as The murder of Yara Gambirasio. We base the analysis on a model for DNA mixtures that takes fully into account the peak heights and possible artefacts, like stutter and dropout that might occur in the DNA amplification process. We show how to combine the evidence from multiple samples and from different marker systems all within the model framework. The combined evidence is used for deconvolution, where the focus is to find likely profiles for the donors to the sample. We also show how a mixture can be used to establish familial relationships between a reference profile and a donor to the mixed DNA sample. We compare results based on a single mixed DNA profile, combination of replicates, combinations of different samples and combinations of different kits. Based on the Yara case, we discuss just a few of the plethora of possibilities of combining evidential information.

KW - Combining evidence

KW - DNA mixtures

KW - Forensic statistics

KW - Kinship

KW - Likelihood ratio

KW - Mixture deconvolution

KW - Probabilistic genotyping

U2 - 10.1016/j.fsigen.2018.12.010

DO - 10.1016/j.fsigen.2018.12.010

M3 - Journal article

C2 - 30776772

AN - SCOPUS:85061538758

VL - 40

SP - 52

EP - 63

JO - Forensic Science International: Genetics

JF - Forensic Science International: Genetics

SN - 1872-4973

ER -

ID: 241100799