Absorption and initial metabolism of 75Se-l-selenomethionine: a kinetic model based on dynamic scintigraphic data
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Absorption and initial metabolism of 75Se-l-selenomethionine : a kinetic model based on dynamic scintigraphic data. / Grosse Ruse, Mareile; Søndergaard, Lasse R. ; Ditlevsen, Susanne; Damgaard, Morten ; Fuglsang, Stefan; Ottesen, Johnny T. ; Madsen, Jan L. .
I: British Journal of Nutrition, Bind 114, Nr. 10, 2015, s. 1718-1723.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Absorption and initial metabolism of 75Se-l-selenomethionine
T2 - a kinetic model based on dynamic scintigraphic data
AU - Grosse Ruse, Mareile
AU - Søndergaard, Lasse R.
AU - Ditlevsen, Susanne
AU - Damgaard, Morten
AU - Fuglsang, Stefan
AU - Ottesen, Johnny T.
AU - Madsen, Jan L.
PY - 2015
Y1 - 2015
N2 - Selenomethionine (SeMet) is an important organic nutritional source of Se, but the uptake and metabolism of SeMet are poorly characterised in humans. Dynamic gamma camera images of the abdominal region were acquired from eight healthy young men after the ingestion of radioactive 75Se-l-SeMet (75Se-SeMet). Scanning started simultaneously to the ingestion of 75Se-SeMet and lasted 120 min. We generated time-activity curves from two-dimensional regions of interest in the stomach, small intestine and liver. During scanning, blood samples were collected at 10-min intervals to generate plasma time-activity curves. A four-compartment model, augmented with a delay between the liver and plasma, was fitted to individual participants’ data. The mean rate constant for 75Se-SeMet transport was 2·63 h–1 from the stomach to the small intestine, 13·2 h–1 from the small intestine to the liver, 0·261 h–1 from the liver to the plasma and 0·267 h–1 from the stomach to the plasma. The delay in the liver was 0·714 h. Gamma camera imaging provides data for use in compartmental modelling of 75Se-SeMet absorption and metabolism in humans. In clinical settings, the obtained rate constants and the delay in the liver may be useful variables for quantifying reduced intestinal absorption capacity or liver function.
AB - Selenomethionine (SeMet) is an important organic nutritional source of Se, but the uptake and metabolism of SeMet are poorly characterised in humans. Dynamic gamma camera images of the abdominal region were acquired from eight healthy young men after the ingestion of radioactive 75Se-l-SeMet (75Se-SeMet). Scanning started simultaneously to the ingestion of 75Se-SeMet and lasted 120 min. We generated time-activity curves from two-dimensional regions of interest in the stomach, small intestine and liver. During scanning, blood samples were collected at 10-min intervals to generate plasma time-activity curves. A four-compartment model, augmented with a delay between the liver and plasma, was fitted to individual participants’ data. The mean rate constant for 75Se-SeMet transport was 2·63 h–1 from the stomach to the small intestine, 13·2 h–1 from the small intestine to the liver, 0·261 h–1 from the liver to the plasma and 0·267 h–1 from the stomach to the plasma. The delay in the liver was 0·714 h. Gamma camera imaging provides data for use in compartmental modelling of 75Se-SeMet absorption and metabolism in humans. In clinical settings, the obtained rate constants and the delay in the liver may be useful variables for quantifying reduced intestinal absorption capacity or liver function.
U2 - 10.1017/S000711451500344X
DO - 10.1017/S000711451500344X
M3 - Journal article
VL - 114
SP - 1718
EP - 1723
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 10
ER -
ID: 148642706