The Morris-Lecar neuron model embeds a leaky integrate-and-fire model

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We showthat the stochastic Morris–Lecar neuron, in a neighborhood of its
stable point, can be approximated by a two-dimensional Ornstein Uhlenbeck (OU) modulation of a constant circular motion. The associated radial OU process is an
example of a leaky integrate-and-fire (LIF) model prior to firing. A new model constructed from a radial OU process together with a simple firing mechanism based on detailedMorris–Lecar firing statistics reproduces theMorris–Lecar Interspike Interval
(ISI) distribution, and has the computational advantages of a LIF. The result justifies the large amount of attention paid to the LIF models.
Original languageEnglish
JournalJournal of Mathematical Biology
Volume67
Issue number2
Pages (from-to)239-259
ISSN0303-6812
DOIs
Publication statusPublished - 2013

ID: 47934163