Interval Walking Improves Glycemic Control and Body Composition After Cancer Treatment: A Randomized Controlled Trial
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Interval Walking Improves Glycemic Control and Body Composition After Cancer Treatment : A Randomized Controlled Trial. / Christensen, Jesper F.; Sundberg, Anna; Osterkamp, Jens; Thorsen-Streit, Sarah; Nielsen, Anette B.; Olsen, Cecilie K.; Djurhuus, Sissal S.; Simonsen, Casper; Schauer, Tim; Ellingsgaard, Helga; Østerlind, Kell; Krarup, Peter Martin; Mosgaard, Camilla; Vistisen, Kirsten; Tolver, Anders; Pedersen, Bente K.; Hojman, Pernille.
In: The Journal of clinical endocrinology and metabolism, Vol. 104, No. 9, 2019, p. 3701-3712.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Interval Walking Improves Glycemic Control and Body Composition After Cancer Treatment
T2 - A Randomized Controlled Trial
AU - Christensen, Jesper F.
AU - Sundberg, Anna
AU - Osterkamp, Jens
AU - Thorsen-Streit, Sarah
AU - Nielsen, Anette B.
AU - Olsen, Cecilie K.
AU - Djurhuus, Sissal S.
AU - Simonsen, Casper
AU - Schauer, Tim
AU - Ellingsgaard, Helga
AU - Østerlind, Kell
AU - Krarup, Peter Martin
AU - Mosgaard, Camilla
AU - Vistisen, Kirsten
AU - Tolver, Anders
AU - Pedersen, Bente K.
AU - Hojman, Pernille
PY - 2019
Y1 - 2019
N2 - CONTEXT: Patients with colorectal cancer have increased risk of metabolic diseases including diabetes. Exercise training may counteract metabolic dysregulation, but the impact of exercise training on glycemic control, including postprandial glycemia, has never been explored in patients with colorectal cancer. OBJECTIVE: To examine the effects of home-based interval walking on aerobic and metabolic fitness and quality of life in patients with colorectal cancer. DESIGN: Randomized controlled trial. SETTING: Clinical research center. PARTICIPANTS: Thirty-nine sedentary (<150 minutes moderate-intensity exercise per week) patients with stage I to III colorectal cancer who had completed primary treatment. INTERVENTION: Home-based interval walking 150 min/wk or usual care for 12 weeks. MAIN OUTCOME MEASURES: Changes from baseline to week 12 in maximum oxygen uptake (VO2peak) by cardiopulmonary exercise test, glycemic control by oral glucose tolerance test (OGTT), body composition by dual-energy x-ray absorptiometry scan, blood biochemistry, and quality of life. RESULTS: Compared with control, interval walking had no effect on VO2peak [mean between-group difference: -0.32 mL O2 · kg-1 · min-1 (-2.09 to 1.45); P = 0.721] but significantly improved postprandial glycemic control with lower glucose OGTT area under the curve [-126 mM · min (-219 to -33); P = 0.009], 2-hour glucose concentration [-1.1 mM (-2.2 to 0.0); P = 0.056], and improved Matsuda index [1.94 (0.34; 3.54); P = 0.01]. Also, interval walking counteracted an increase in fat mass in the control group [-1.47 kg (-2.74 to -0.19); P = 0.025]. CONCLUSION: A home-based interval-walking program led to substantial improvements in postprandial glycemic control and counteracted fat gain in posttreatment patients with colorectal cancer, possibly providing an effective strategy for prevention of secondary metabolic diseases.
AB - CONTEXT: Patients with colorectal cancer have increased risk of metabolic diseases including diabetes. Exercise training may counteract metabolic dysregulation, but the impact of exercise training on glycemic control, including postprandial glycemia, has never been explored in patients with colorectal cancer. OBJECTIVE: To examine the effects of home-based interval walking on aerobic and metabolic fitness and quality of life in patients with colorectal cancer. DESIGN: Randomized controlled trial. SETTING: Clinical research center. PARTICIPANTS: Thirty-nine sedentary (<150 minutes moderate-intensity exercise per week) patients with stage I to III colorectal cancer who had completed primary treatment. INTERVENTION: Home-based interval walking 150 min/wk or usual care for 12 weeks. MAIN OUTCOME MEASURES: Changes from baseline to week 12 in maximum oxygen uptake (VO2peak) by cardiopulmonary exercise test, glycemic control by oral glucose tolerance test (OGTT), body composition by dual-energy x-ray absorptiometry scan, blood biochemistry, and quality of life. RESULTS: Compared with control, interval walking had no effect on VO2peak [mean between-group difference: -0.32 mL O2 · kg-1 · min-1 (-2.09 to 1.45); P = 0.721] but significantly improved postprandial glycemic control with lower glucose OGTT area under the curve [-126 mM · min (-219 to -33); P = 0.009], 2-hour glucose concentration [-1.1 mM (-2.2 to 0.0); P = 0.056], and improved Matsuda index [1.94 (0.34; 3.54); P = 0.01]. Also, interval walking counteracted an increase in fat mass in the control group [-1.47 kg (-2.74 to -0.19); P = 0.025]. CONCLUSION: A home-based interval-walking program led to substantial improvements in postprandial glycemic control and counteracted fat gain in posttreatment patients with colorectal cancer, possibly providing an effective strategy for prevention of secondary metabolic diseases.
UR - http://www.scopus.com/inward/record.url?scp=85070181411&partnerID=8YFLogxK
U2 - 10.1210/jc.2019-00590
DO - 10.1210/jc.2019-00590
M3 - Journal article
C2 - 31220283
AN - SCOPUS:85070181411
VL - 104
SP - 3701
EP - 3712
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 9
ER -
ID: 226873052