Chlormezanone in the Treatment of Migraine Attacks: A Double Blind Comparison with Diazepam and Placebo

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Chlormezanone in the Treatment of Migraine Attacks : A Double Blind Comparison with Diazepam and Placebo. / Tfelt-Hansen, Peer; Jensen, Kai; Vendsborg, Per; Lauritzen, Martin; Olesen, Jes.

In: Cephalalgia, Vol. 2, No. 4, 01.01.1982, p. 205-210.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tfelt-Hansen, P, Jensen, K, Vendsborg, P, Lauritzen, M & Olesen, J 1982, 'Chlormezanone in the Treatment of Migraine Attacks: A Double Blind Comparison with Diazepam and Placebo', Cephalalgia, vol. 2, no. 4, pp. 205-210. https://doi.org/10.1046/j.1468-2982.1982.0204205.x

APA

Tfelt-Hansen, P., Jensen, K., Vendsborg, P., Lauritzen, M., & Olesen, J. (1982). Chlormezanone in the Treatment of Migraine Attacks: A Double Blind Comparison with Diazepam and Placebo. Cephalalgia, 2(4), 205-210. https://doi.org/10.1046/j.1468-2982.1982.0204205.x

Vancouver

Tfelt-Hansen P, Jensen K, Vendsborg P, Lauritzen M, Olesen J. Chlormezanone in the Treatment of Migraine Attacks: A Double Blind Comparison with Diazepam and Placebo. Cephalalgia. 1982 Jan 1;2(4):205-210. https://doi.org/10.1046/j.1468-2982.1982.0204205.x

Author

Tfelt-Hansen, Peer ; Jensen, Kai ; Vendsborg, Per ; Lauritzen, Martin ; Olesen, Jes. / Chlormezanone in the Treatment of Migraine Attacks : A Double Blind Comparison with Diazepam and Placebo. In: Cephalalgia. 1982 ; Vol. 2, No. 4. pp. 205-210.

Bibtex

@article{f93e161af544434a94fdff8d7681fb1c,
title = "Chlormezanone in the Treatment of Migraine Attacks: A Double Blind Comparison with Diazepam and Placebo",
abstract = "One hundred and fifty patients treated for an acute migraine attack all received a standard regimen consisting of metoclopramide 10 mg i.m. and—20 min later—paracetamol 1 g orally. Simultaneous trial medication was given. This consisted of placebo, diazepam 5 mg as tablets, or chlormezanone 400 mg as capsules given in a double dummy fashion. A successful treatment result was defined as a decrease of two or three steps on a four-point verbal pain report scale, and no need for further treatment. Patients with severe pain (all three treatment groups together) showed significantly better treatment results (p < 0.001) than patients with pain of medium severity. In the group with severe pain there was no significant difference between diazepam, chlormezanone or placebo. In the group with pain of medium severity there was a significant (p < 0.01) effect of chlormezanone, but no significant effect of diazepam. Chlormezanone may possibly be a valuable addition to antiemetic and analgesic therapy of migraine attacks.",
author = "Peer Tfelt-Hansen and Kai Jensen and Per Vendsborg and Martin Lauritzen and Jes Olesen",
year = "1982",
month = jan,
day = "1",
doi = "10.1046/j.1468-2982.1982.0204205.x",
language = "English",
volume = "2",
pages = "205--210",
journal = "Cephalalgia",
issn = "0800-1952",
publisher = "SAGE Publications",
number = "4",

}

RIS

TY - JOUR

T1 - Chlormezanone in the Treatment of Migraine Attacks

T2 - A Double Blind Comparison with Diazepam and Placebo

AU - Tfelt-Hansen, Peer

AU - Jensen, Kai

AU - Vendsborg, Per

AU - Lauritzen, Martin

AU - Olesen, Jes

PY - 1982/1/1

Y1 - 1982/1/1

N2 - One hundred and fifty patients treated for an acute migraine attack all received a standard regimen consisting of metoclopramide 10 mg i.m. and—20 min later—paracetamol 1 g orally. Simultaneous trial medication was given. This consisted of placebo, diazepam 5 mg as tablets, or chlormezanone 400 mg as capsules given in a double dummy fashion. A successful treatment result was defined as a decrease of two or three steps on a four-point verbal pain report scale, and no need for further treatment. Patients with severe pain (all three treatment groups together) showed significantly better treatment results (p < 0.001) than patients with pain of medium severity. In the group with severe pain there was no significant difference between diazepam, chlormezanone or placebo. In the group with pain of medium severity there was a significant (p < 0.01) effect of chlormezanone, but no significant effect of diazepam. Chlormezanone may possibly be a valuable addition to antiemetic and analgesic therapy of migraine attacks.

AB - One hundred and fifty patients treated for an acute migraine attack all received a standard regimen consisting of metoclopramide 10 mg i.m. and—20 min later—paracetamol 1 g orally. Simultaneous trial medication was given. This consisted of placebo, diazepam 5 mg as tablets, or chlormezanone 400 mg as capsules given in a double dummy fashion. A successful treatment result was defined as a decrease of two or three steps on a four-point verbal pain report scale, and no need for further treatment. Patients with severe pain (all three treatment groups together) showed significantly better treatment results (p < 0.001) than patients with pain of medium severity. In the group with severe pain there was no significant difference between diazepam, chlormezanone or placebo. In the group with pain of medium severity there was a significant (p < 0.01) effect of chlormezanone, but no significant effect of diazepam. Chlormezanone may possibly be a valuable addition to antiemetic and analgesic therapy of migraine attacks.

UR - http://www.scopus.com/inward/record.url?scp=0020413696&partnerID=8YFLogxK

U2 - 10.1046/j.1468-2982.1982.0204205.x

DO - 10.1046/j.1468-2982.1982.0204205.x

M3 - Journal article

C2 - 6760981

AN - SCOPUS:0020413696

VL - 2

SP - 205

EP - 210

JO - Cephalalgia

JF - Cephalalgia

SN - 0800-1952

IS - 4

ER -

ID: 201459554