Simulating haplotype blocks in the human genome

Research output: Contribution to journalJournal articleResearchpeer-review

A bioinformatic tool was written to simulate haplotypes and SNPs under a modified coalescent with recombination. The most important feature of this program is that it allows for the specification of non-homogeneous recombination rates, which results in the formation of the so-called 'haplotype blocks' of the human genome. The program also implements different mutation models and flexible demographic histories. The samples generated can be very useful to better understand the architecture of the human genome and to investigate its impact in association studies searching for disease genes.

Original languageEnglish
JournalBioinformatics
Volume19
Issue number2
Pages (from-to)289-290
Number of pages2
ISSN1367-4803
DOIs
Publication statusPublished - 1 Feb 2003
Externally publishedYes

ID: 203902757