Do ΔF508 heterozygotes have a selective advantage?

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Do ΔF508 heterozygotes have a selective advantage? / Wiuf, C.

In: Genetical Research, Vol. 78, No. 1, 29.08.2001, p. 41-47.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wiuf, C 2001, 'Do ΔF508 heterozygotes have a selective advantage?', Genetical Research, vol. 78, no. 1, pp. 41-47. https://doi.org/10.1017/S0016672301005195

APA

Wiuf, C. (2001). Do ΔF508 heterozygotes have a selective advantage? Genetical Research, 78(1), 41-47. https://doi.org/10.1017/S0016672301005195

Vancouver

Wiuf C. Do ΔF508 heterozygotes have a selective advantage? Genetical Research. 2001 Aug 29;78(1):41-47. https://doi.org/10.1017/S0016672301005195

Author

Wiuf, C. / Do ΔF508 heterozygotes have a selective advantage?. In: Genetical Research. 2001 ; Vol. 78, No. 1. pp. 41-47.

Bibtex

@article{040d6e96e0164d76b2ac990d30b34338,
title = "Do ΔF508 heterozygotes have a selective advantage?",
abstract = "In this paper the fitness of the ΔF508 heterozygote is assessed and the age of the ΔF508 mutation in the cystic fibrosis locus is estimated. Data from three microsatellite loci are applied. The analysis is performed conditional on the present-day frequency of the ΔF508 mutation and based on assumptions about the demographic history of the European population and the mutation rate in the three microsatellite loci. It is shown that the data gives evidence of positive selection (up to 2-3% per ΔF508 heterozygote), but also that data could be explained by negative selection of roughly the same order of magnitude. The age of the ΔF508 mutation is subsequently estimated; it is found that the mutation is at least 580 generations old, but could be much older depending on the microsatellite mutation rate and the exact number of substitutions experienced in the history of the three microsatellite loci.",
author = "C. Wiuf",
year = "2001",
month = aug,
day = "29",
doi = "10.1017/S0016672301005195",
language = "English",
volume = "78",
pages = "41--47",
journal = "Genetics Research",
issn = "0016-6723",
publisher = "Cambridge University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Do ΔF508 heterozygotes have a selective advantage?

AU - Wiuf, C.

PY - 2001/8/29

Y1 - 2001/8/29

N2 - In this paper the fitness of the ΔF508 heterozygote is assessed and the age of the ΔF508 mutation in the cystic fibrosis locus is estimated. Data from three microsatellite loci are applied. The analysis is performed conditional on the present-day frequency of the ΔF508 mutation and based on assumptions about the demographic history of the European population and the mutation rate in the three microsatellite loci. It is shown that the data gives evidence of positive selection (up to 2-3% per ΔF508 heterozygote), but also that data could be explained by negative selection of roughly the same order of magnitude. The age of the ΔF508 mutation is subsequently estimated; it is found that the mutation is at least 580 generations old, but could be much older depending on the microsatellite mutation rate and the exact number of substitutions experienced in the history of the three microsatellite loci.

AB - In this paper the fitness of the ΔF508 heterozygote is assessed and the age of the ΔF508 mutation in the cystic fibrosis locus is estimated. Data from three microsatellite loci are applied. The analysis is performed conditional on the present-day frequency of the ΔF508 mutation and based on assumptions about the demographic history of the European population and the mutation rate in the three microsatellite loci. It is shown that the data gives evidence of positive selection (up to 2-3% per ΔF508 heterozygote), but also that data could be explained by negative selection of roughly the same order of magnitude. The age of the ΔF508 mutation is subsequently estimated; it is found that the mutation is at least 580 generations old, but could be much older depending on the microsatellite mutation rate and the exact number of substitutions experienced in the history of the three microsatellite loci.

UR - http://www.scopus.com/inward/record.url?scp=0034891467&partnerID=8YFLogxK

U2 - 10.1017/S0016672301005195

DO - 10.1017/S0016672301005195

M3 - Journal article

C2 - 11556136

AN - SCOPUS:0034891467

VL - 78

SP - 41

EP - 47

JO - Genetics Research

JF - Genetics Research

SN - 0016-6723

IS - 1

ER -

ID: 203903084