Modelling the contribution of family history and variation in single nucleotide polymorphisms to risk of schizophrenia: a Danish national birth cohort-based study

Research output: Contribution to journalJournal articleResearchpeer-review

  • Esben Agerbo
  • Preben Bo Mortensen
  • Wiuf, Carsten
  • Michael S Pedersen
  • John McGrath
  • Mads Vilhelm Hollegaard
  • Bent Nørgaard-Pedersen
  • David M Hougaard
  • Ole Mors
  • Carsten B Pedersen
Epidemiological studies indicate that having any family member with schizophrenia increases the risk of schizophrenia in the probands. However, genome-wide association studies (GWAS) have accounted for little of this variation. The aim of this study was to use a population-based sample to explore the influence of single-nucleotide polymorphisms (SNPs) on the excess schizophrenia risk in offspring of parents with a psychotic, bipolar affective or other psychiatric disorder.
Original languageEnglish
JournalSchizophrenia Research
Volume134
Issue number2-3
Pages (from-to)246-252
Number of pages7
ISSN0920-9964
DOIs
Publication statusPublished - 2012

    Research areas

  • Cohort Studies, Community Health Planning, Denmark, Family Health, Female, Genetic Predisposition to Disease, Genetics, Population, Genome-Wide Association Study, Humans, Male, Polymorphism, Single Nucleotide, Psychotic Disorders, Risk, Schizophrenia

ID: 40763541