TY - JOUR

T1 - A coalescence approach to gene conversion

AU - Wiuf, Carsten

PY - 2000/1/1

Y1 - 2000/1/1

N2 - In this paper we develop a coalescent model with intralocus gene conversion. Such models are of increasing importance in the analysis of intralocus variability and linkage disequilibrium. We derive the distribution of the waiting time until a gene conversion event occurs in a sample in terms of the distribution of the length of the transferred segment, ζ. We do not assume any specific form of the distribution of ζ. Further, given that a gene conversion event occurs we find the distribution of (σ, τ), the end points of the transferred segment and derive results on correlations between local trees in positions X1 and X1. Among other results we show that the correlation between the branch lengths of two local trees in the coalescent with gene conversion (and no recombination) decreases toward a nonzero constant when the distance between X1 and X1 increases. Finally, we show that a model including both recombination and gene conversion might account for the lack of intralocus associations found in, e.g., Drosophila melanogaster. (C) 2000 Academic Press.

AB - In this paper we develop a coalescent model with intralocus gene conversion. Such models are of increasing importance in the analysis of intralocus variability and linkage disequilibrium. We derive the distribution of the waiting time until a gene conversion event occurs in a sample in terms of the distribution of the length of the transferred segment, ζ. We do not assume any specific form of the distribution of ζ. Further, given that a gene conversion event occurs we find the distribution of (σ, τ), the end points of the transferred segment and derive results on correlations between local trees in positions X1 and X1. Among other results we show that the correlation between the branch lengths of two local trees in the coalescent with gene conversion (and no recombination) decreases toward a nonzero constant when the distance between X1 and X1 increases. Finally, we show that a model including both recombination and gene conversion might account for the lack of intralocus associations found in, e.g., Drosophila melanogaster. (C) 2000 Academic Press.

KW - Coalescent model

KW - Gene conversion

KW - Intralocus variability

KW - Linkage disequilibrium

KW - Recombination

UR - http://www.scopus.com/inward/record.url?scp=0033907068&partnerID=8YFLogxK

U2 - 10.1006/tpbi.2000.1462

DO - 10.1006/tpbi.2000.1462

M3 - Journal article

C2 - 10900188

AN - SCOPUS:0033907068

VL - 57

SP - 357

EP - 367

JO - Theoretical Population Biology

JF - Theoretical Population Biology

SN - 0040-5809

IS - 4

ER -