Simulating haplotype blocks in the human genome

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

A bioinformatic tool was written to simulate haplotypes and SNPs under a modified coalescent with recombination. The most important feature of this program is that it allows for the specification of non-homogeneous recombination rates, which results in the formation of the so-called 'haplotype blocks' of the human genome. The program also implements different mutation models and flexible demographic histories. The samples generated can be very useful to better understand the architecture of the human genome and to investigate its impact in association studies searching for disease genes.

OriginalsprogEngelsk
TidsskriftBioinformatics
Vol/bind19
Udgave nummer2
Sider (fra-til)289-290
Antal sider2
ISSN1367-4803
DOI
StatusUdgivet - 1 feb. 2003
Eksternt udgivetJa

ID: 203902757