Short tandem repeats and genetic variation

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Standard

Short tandem repeats and genetic variation. / Madsen, Bo Eskerod; Villesen, Palle; Wiuf, Carsten.

Genetic Variation: Methods and Protocols. Humana Press, 2010. s. 297-306 (Methods in Molecular Biology, Bind 628).

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Harvard

Madsen, BE, Villesen, P & Wiuf, C 2010, Short tandem repeats and genetic variation. i Genetic Variation: Methods and Protocols. Humana Press, Methods in Molecular Biology, bind 628, s. 297-306. https://doi.org/10.1007/978-1-60327-367-1_16

APA

Madsen, B. E., Villesen, P., & Wiuf, C. (2010). Short tandem repeats and genetic variation. I Genetic Variation: Methods and Protocols (s. 297-306). Humana Press. Methods in Molecular Biology Bind 628 https://doi.org/10.1007/978-1-60327-367-1_16

Vancouver

Madsen BE, Villesen P, Wiuf C. Short tandem repeats and genetic variation. I Genetic Variation: Methods and Protocols. Humana Press. 2010. s. 297-306. (Methods in Molecular Biology, Bind 628). https://doi.org/10.1007/978-1-60327-367-1_16

Author

Madsen, Bo Eskerod ; Villesen, Palle ; Wiuf, Carsten. / Short tandem repeats and genetic variation. Genetic Variation: Methods and Protocols. Humana Press, 2010. s. 297-306 (Methods in Molecular Biology, Bind 628).

Bibtex

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title = "Short tandem repeats and genetic variation",
abstract = "Single nucleotide polymorphisms (SNPs) are widely distributed in the human genome and although most SNPs are the result of independent point-mutations, there are exceptions. When studying distances between SNPs, a periodic pattern in the distance between pairs of identical SNPs has been found to be heavily correlated with periodicity in short tandem repeats (STRs). STRs are short DNA segments, widely distributed in the human genome and mainly found outside known tandem repeats. Because of the biased occurrence of SNPs, special care has to be taken when analyzing SNP-variation in STRs. We present a review of STRs in the human genome and discuss molecular mechanisms related to the biased occurrence of SNPs in STRs, and its implications for genome comparisons and genetic association studies.",
keywords = "Mechanism, Mutation, Pattern, Polymorphism, Short tandem repeat, SNPs, Variation",
author = "Madsen, {Bo Eskerod} and Palle Villesen and Carsten Wiuf",
year = "2010",
month = jan,
day = "1",
doi = "10.1007/978-1-60327-367-1_16",
language = "English",
isbn = "9781603273664",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "297--306",
booktitle = "Genetic Variation",
address = "United States",

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RIS

TY - CHAP

T1 - Short tandem repeats and genetic variation

AU - Madsen, Bo Eskerod

AU - Villesen, Palle

AU - Wiuf, Carsten

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Single nucleotide polymorphisms (SNPs) are widely distributed in the human genome and although most SNPs are the result of independent point-mutations, there are exceptions. When studying distances between SNPs, a periodic pattern in the distance between pairs of identical SNPs has been found to be heavily correlated with periodicity in short tandem repeats (STRs). STRs are short DNA segments, widely distributed in the human genome and mainly found outside known tandem repeats. Because of the biased occurrence of SNPs, special care has to be taken when analyzing SNP-variation in STRs. We present a review of STRs in the human genome and discuss molecular mechanisms related to the biased occurrence of SNPs in STRs, and its implications for genome comparisons and genetic association studies.

AB - Single nucleotide polymorphisms (SNPs) are widely distributed in the human genome and although most SNPs are the result of independent point-mutations, there are exceptions. When studying distances between SNPs, a periodic pattern in the distance between pairs of identical SNPs has been found to be heavily correlated with periodicity in short tandem repeats (STRs). STRs are short DNA segments, widely distributed in the human genome and mainly found outside known tandem repeats. Because of the biased occurrence of SNPs, special care has to be taken when analyzing SNP-variation in STRs. We present a review of STRs in the human genome and discuss molecular mechanisms related to the biased occurrence of SNPs in STRs, and its implications for genome comparisons and genetic association studies.

KW - Mechanism

KW - Mutation

KW - Pattern

KW - Polymorphism

KW - Short tandem repeat

KW - SNPs

KW - Variation

UR - http://www.scopus.com/inward/record.url?scp=77952562405&partnerID=8YFLogxK

U2 - 10.1007/978-1-60327-367-1_16

DO - 10.1007/978-1-60327-367-1_16

M3 - Book chapter

C2 - 20238088

AN - SCOPUS:77952562405

SN - 9781603273664

T3 - Methods in Molecular Biology

SP - 297

EP - 306

BT - Genetic Variation

PB - Humana Press

ER -

ID: 203900071