Rare alleles and selection

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Rare alleles and selection. / Wiuf, Carsten.

I: Theoretical Population Biology, Bind 59, Nr. 4, 01.01.2001, s. 287-296.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Wiuf, C 2001, 'Rare alleles and selection', Theoretical Population Biology, bind 59, nr. 4, s. 287-296. https://doi.org/10.1006/tpbi.2001.1523

APA

Wiuf, C. (2001). Rare alleles and selection. Theoretical Population Biology, 59(4), 287-296. https://doi.org/10.1006/tpbi.2001.1523

Vancouver

Wiuf C. Rare alleles and selection. Theoretical Population Biology. 2001 jan. 1;59(4):287-296. https://doi.org/10.1006/tpbi.2001.1523

Author

Wiuf, Carsten. / Rare alleles and selection. I: Theoretical Population Biology. 2001 ; Bind 59, Nr. 4. s. 287-296.

Bibtex

@article{776bb91a04a84313971d8d629a0f7a78,
title = "Rare alleles and selection",
abstract = "A subpopulation D of rare alleles is considered. The subpopulation is part of a large population that evolves according to a Moran model with selection and growth. Conditional on the current frequency, q, of the rare allele, an approximation to the distribution of the genealogy of D is derived. In particular, the density of the age, T1, of the rare allele is approximated, It is shown that time naturally is measured in units of qN(0) generations, where N(0) is the present day population size, and that the distribution of the genealogy of D depends on the compound parameters ρ=rqN(O) and σ=sqN(O) only. Here, s is the fitness per generation of heterozygote carriers of the rare allele and r is the growth rate per generation of the population. Amongst more, it is shown that for constant population size (ρ=0) the distribution of D depends on σ only through the absolute value |σ|, not the direction of selection.",
keywords = "Birth-death process, Exponential growth, Genealogy, Rare allele, Selection",
author = "Carsten Wiuf",
year = "2001",
month = jan,
day = "1",
doi = "10.1006/tpbi.2001.1523",
language = "English",
volume = "59",
pages = "287--296",
journal = "Theoretical Population Biology",
issn = "0040-5809",
publisher = "Academic Press",
number = "4",

}

RIS

TY - JOUR

T1 - Rare alleles and selection

AU - Wiuf, Carsten

PY - 2001/1/1

Y1 - 2001/1/1

N2 - A subpopulation D of rare alleles is considered. The subpopulation is part of a large population that evolves according to a Moran model with selection and growth. Conditional on the current frequency, q, of the rare allele, an approximation to the distribution of the genealogy of D is derived. In particular, the density of the age, T1, of the rare allele is approximated, It is shown that time naturally is measured in units of qN(0) generations, where N(0) is the present day population size, and that the distribution of the genealogy of D depends on the compound parameters ρ=rqN(O) and σ=sqN(O) only. Here, s is the fitness per generation of heterozygote carriers of the rare allele and r is the growth rate per generation of the population. Amongst more, it is shown that for constant population size (ρ=0) the distribution of D depends on σ only through the absolute value |σ|, not the direction of selection.

AB - A subpopulation D of rare alleles is considered. The subpopulation is part of a large population that evolves according to a Moran model with selection and growth. Conditional on the current frequency, q, of the rare allele, an approximation to the distribution of the genealogy of D is derived. In particular, the density of the age, T1, of the rare allele is approximated, It is shown that time naturally is measured in units of qN(0) generations, where N(0) is the present day population size, and that the distribution of the genealogy of D depends on the compound parameters ρ=rqN(O) and σ=sqN(O) only. Here, s is the fitness per generation of heterozygote carriers of the rare allele and r is the growth rate per generation of the population. Amongst more, it is shown that for constant population size (ρ=0) the distribution of D depends on σ only through the absolute value |σ|, not the direction of selection.

KW - Birth-death process

KW - Exponential growth

KW - Genealogy

KW - Rare allele

KW - Selection

UR - http://www.scopus.com/inward/record.url?scp=0034904873&partnerID=8YFLogxK

U2 - 10.1006/tpbi.2001.1523

DO - 10.1006/tpbi.2001.1523

M3 - Journal article

C2 - 11560449

AN - SCOPUS:0034904873

VL - 59

SP - 287

EP - 296

JO - Theoretical Population Biology

JF - Theoretical Population Biology

SN - 0040-5809

IS - 4

ER -

ID: 203901867