Nonnegative linear elimination for chemical reaction networks

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We consider linear elimination of variables in the steady state equations of a chem- ical reaction network. Particular subsets of variables corresponding to sets of so-called reactant- noninteracting species, are introduced. The steady state equations for the variables in such a set, taken together with potential linear conservation laws in the variables, define a linear system of equa- tions. We give conditions that guarantee that the solution to this system is nonnegative, provided it is unique. The results are framed in terms of spanning forests of a particular multidigraph derived from the reaction network and thereby conditions for uniqueness and nonnegativity of a solution are derived by means of the multidigraph. Though our motivation comes from applications in systems biology, the results have general applicability in applied sciences.

OriginalsprogEngelsk
TidsskriftSIAM Journal on Applied Mathematics
Vol/bind79
Udgave nummer6
Sider (fra-til)2434-2455
ISSN0036-1399
DOI
StatusUdgivet - 2019

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