Intense synaptic activity enhances temporal resolution in spinal motoneurons
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Intense synaptic activity enhances temporal resolution in spinal motoneurons. / Berg, Rune W; Ditlevsen, Susanne; Hounsgaard, Jørn Dybkjær.
I: PLoS ONE, Bind 3, Nr. 9, 2008, s. e3218.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Intense synaptic activity enhances temporal resolution in spinal motoneurons
AU - Berg, Rune W
AU - Ditlevsen, Susanne
AU - Hounsgaard, Jørn Dybkjær
N1 - Paper id:: doi:10.1371/journal.pone.0003218
PY - 2008
Y1 - 2008
N2 - In neurons, spike timing is determined by integration of synaptic potentials in delicate concert with intrinsic properties. Although the integration time is functionally crucial, it remains elusive during network activity. While mechanisms of rapid processing are well documented in sensory systems, agility in motor systems has received little attention. Here we analyze how intense synaptic activity affects integration time in spinal motoneurons during functional motor activity and report a 10-fold decrease. As a result, action potentials can only be predicted from the membrane potential within 10 ms of their occurrence and detected for less than 10 ms after their occurrence. Being shorter than the average inter-spike interval, the AHP has little effect on integration time and spike timing, which instead is entirely determined by fluctuations in membrane potential caused by the barrage of inhibitory and excitatory synaptic activity. By shortening the effective integration time, this intense synaptic input may serve to facilitate the generation of rapid changes in movements.
AB - In neurons, spike timing is determined by integration of synaptic potentials in delicate concert with intrinsic properties. Although the integration time is functionally crucial, it remains elusive during network activity. While mechanisms of rapid processing are well documented in sensory systems, agility in motor systems has received little attention. Here we analyze how intense synaptic activity affects integration time in spinal motoneurons during functional motor activity and report a 10-fold decrease. As a result, action potentials can only be predicted from the membrane potential within 10 ms of their occurrence and detected for less than 10 ms after their occurrence. Being shorter than the average inter-spike interval, the AHP has little effect on integration time and spike timing, which instead is entirely determined by fluctuations in membrane potential caused by the barrage of inhibitory and excitatory synaptic activity. By shortening the effective integration time, this intense synaptic input may serve to facilitate the generation of rapid changes in movements.
KW - Action Potentials
KW - Animals
KW - Computer Simulation
KW - Electric Conductivity
KW - Electrophysiology
KW - Membrane Potentials
KW - Models, Statistical
KW - Motor Activity
KW - Motor Neurons
KW - Neurons
KW - Spinal Cord
KW - Stochastic Processes
KW - Synapses
KW - Synaptic Potentials
KW - Time Factors
KW - Turtles
U2 - 10.1371/journal.pone.0003218
DO - 10.1371/journal.pone.0003218
M3 - Journal article
C2 - 18795101
VL - 3
SP - e3218
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 9
ER -
ID: 8237613