GPCRDB: an information system for G protein-coupled receptors
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GPCRDB : an information system for G protein-coupled receptors. / Ísberg, Vignir; Vroling, Bas; van der Kant, Rob; Li, Kang; Vriend, Gert; Gloriam, David.
I: Nucleic Acids Research, Bind 42, Nr. Database issue, 01.2014, s. D422-D425.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - GPCRDB
T2 - an information system for G protein-coupled receptors
AU - Ísberg, Vignir
AU - Vroling, Bas
AU - van der Kant, Rob
AU - Li, Kang
AU - Vriend, Gert
AU - Gloriam, David
N1 - Funding: Lundbeck Foundation [R54-A5441 to V.I.]; the Carlsberg Foundation [R77-A6854 to D.G.] and the European Union NewProt project [289350 to G.V.]. Funding for open access charge: The publication was paid by the CMBI running costs.
PY - 2014/1
Y1 - 2014/1
N2 - For the past 20 years, the GPCRDB (G protein-coupled receptors database; http://www.gpcr.org/7tm/) has been a 'one-stop shop' for G protein-coupled receptor (GPCR)-related data. The GPCRDB contains experimental data on sequences, ligand-binding constants, mutations and oligomers, as well as many different types of computationally derived data, such as multiple sequence alignments and homology models. The GPCRDB also provides visualization and analysis tools, plus a number of query systems. In the latest GPCRDB release, all multiple sequence alignments, and >65,000 homology models, have been significantly improved, thanks to a recent flurry of GPCR X-ray structure data. Tools were introduced to browse X-ray structures, compare binding sites, profile similar receptors and generate amino acid conservation statistics. Snake plots and helix box diagrams can now be custom coloured (e.g. by chemical properties or mutation data) and saved as figures. A series of sequence alignment visualization tools has been added, and sequence alignments can now be created for subsets of sequences and sequence positions, and alignment statistics can be produced for any of these subsets.
AB - For the past 20 years, the GPCRDB (G protein-coupled receptors database; http://www.gpcr.org/7tm/) has been a 'one-stop shop' for G protein-coupled receptor (GPCR)-related data. The GPCRDB contains experimental data on sequences, ligand-binding constants, mutations and oligomers, as well as many different types of computationally derived data, such as multiple sequence alignments and homology models. The GPCRDB also provides visualization and analysis tools, plus a number of query systems. In the latest GPCRDB release, all multiple sequence alignments, and >65,000 homology models, have been significantly improved, thanks to a recent flurry of GPCR X-ray structure data. Tools were introduced to browse X-ray structures, compare binding sites, profile similar receptors and generate amino acid conservation statistics. Snake plots and helix box diagrams can now be custom coloured (e.g. by chemical properties or mutation data) and saved as figures. A series of sequence alignment visualization tools has been added, and sequence alignments can now be created for subsets of sequences and sequence positions, and alignment statistics can be produced for any of these subsets.
KW - Binding Sites
KW - Databases, Protein
KW - Internet
KW - Receptors, G-Protein-Coupled
KW - Sequence Alignment
KW - Sequence Analysis, Protein
KW - Software
KW - Structural Homology, Protein
U2 - 10.1093/nar/gkt1255
DO - 10.1093/nar/gkt1255
M3 - Journal article
C2 - 24304901
VL - 42
SP - D422-D425
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - Database issue
ER -
ID: 103949426