Are microRNAs located in genomic regions associated with cancer?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Are microRNAs located in genomic regions associated with cancer? / Lamy, P.; Andersen, C. L.; Dyrskjøt, L.; Tørring, N.; Ørntoft, T.; Wiuf, C.

In: British Journal of Cancer, Vol. 95, No. 10, 20.11.2006, p. 1415-1418.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lamy, P, Andersen, CL, Dyrskjøt, L, Tørring, N, Ørntoft, T & Wiuf, C 2006, 'Are microRNAs located in genomic regions associated with cancer?', British Journal of Cancer, vol. 95, no. 10, pp. 1415-1418. https://doi.org/10.1038/sj.bjc.6603381

APA

Lamy, P., Andersen, C. L., Dyrskjøt, L., Tørring, N., Ørntoft, T., & Wiuf, C. (2006). Are microRNAs located in genomic regions associated with cancer? British Journal of Cancer, 95(10), 1415-1418. https://doi.org/10.1038/sj.bjc.6603381

Vancouver

Lamy P, Andersen CL, Dyrskjøt L, Tørring N, Ørntoft T, Wiuf C. Are microRNAs located in genomic regions associated with cancer? British Journal of Cancer. 2006 Nov 20;95(10):1415-1418. https://doi.org/10.1038/sj.bjc.6603381

Author

Lamy, P. ; Andersen, C. L. ; Dyrskjøt, L. ; Tørring, N. ; Ørntoft, T. ; Wiuf, C. / Are microRNAs located in genomic regions associated with cancer?. In: British Journal of Cancer. 2006 ; Vol. 95, No. 10. pp. 1415-1418.

Bibtex

@article{4a36577096c546dba70b86e887dfdef0,
title = "Are microRNAs located in genomic regions associated with cancer?",
abstract = "We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.",
keywords = "Affymetrix SNP array, Bladder, Colon, Copy number, microRNA, Prostate",
author = "P. Lamy and Andersen, {C. L.} and L. Dyrskj{\o}t and N. T{\o}rring and T. {\O}rntoft and C. Wiuf",
year = "2006",
month = nov,
day = "20",
doi = "10.1038/sj.bjc.6603381",
language = "English",
volume = "95",
pages = "1415--1418",
journal = "The British journal of cancer. Supplement",
issn = "0007-0920",
publisher = "nature publishing group",
number = "10",

}

RIS

TY - JOUR

T1 - Are microRNAs located in genomic regions associated with cancer?

AU - Lamy, P.

AU - Andersen, C. L.

AU - Dyrskjøt, L.

AU - Tørring, N.

AU - Ørntoft, T.

AU - Wiuf, C.

PY - 2006/11/20

Y1 - 2006/11/20

N2 - We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.

AB - We report on the location of 283 miRNAs in the human genome in relation to copy number changes in three distinct types of tumours: prostate, bladder and colon. In prostate and colon tumours, we find miRNAs over-represented in regions with copy number gain and under-represented in regions with copy number loss. Surprisingly this pattern appears to be reversed in bladder cancer. We compared our miRNA copy number data to published miRNA expression data; unexpectedly, we did not find a statistically significant relationship between miRNA copy number and expression level. This suggests that miRNA expression is regulated through different mechanisms than mRNA expression.

KW - Affymetrix SNP array

KW - Bladder

KW - Colon

KW - Copy number

KW - microRNA

KW - Prostate

UR - http://www.scopus.com/inward/record.url?scp=33751069186&partnerID=8YFLogxK

U2 - 10.1038/sj.bjc.6603381

DO - 10.1038/sj.bjc.6603381

M3 - Journal article

C2 - 17003783

AN - SCOPUS:33751069186

VL - 95

SP - 1415

EP - 1418

JO - The British journal of cancer. Supplement

JF - The British journal of cancer. Supplement

SN - 0007-0920

IS - 10

ER -

ID: 203903795