The Morris-Lecar neuron model embeds a leaky integrate-and-fire model

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

We showthat the stochastic Morris–Lecar neuron, in a neighborhood of its
stable point, can be approximated by a two-dimensional Ornstein Uhlenbeck (OU) modulation of a constant circular motion. The associated radial OU process is an
example of a leaky integrate-and-fire (LIF) model prior to firing. A new model constructed from a radial OU process together with a simple firing mechanism based on detailedMorris–Lecar firing statistics reproduces theMorris–Lecar Interspike Interval
(ISI) distribution, and has the computational advantages of a LIF. The result justifies the large amount of attention paid to the LIF models.
OriginalsprogEngelsk
TidsskriftJournal of Mathematical Biology
Vol/bind67
Udgave nummer2
Sider (fra-til)239-259
ISSN0303-6812
DOI
StatusUdgivet - 2013

ID: 47934163