An international multi-centre prospective study on the efficacy of an intraarticular polyacrylamide hydrogel in horses with osteoarthritis: A 24months follow-up

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An international multi-centre prospective study on the efficacy of an intraarticular polyacrylamide hydrogel in horses with osteoarthritis : A 24months follow-up. / Tnibar, Aziz; Schougaard, Hans; Camitz, Linus; Rasmussen, Jonas; Koene, Marc; Jahn, Werner; Markussen, Bo.

I: Acta Veterinaria Scandinavica (Online), Bind 57, Nr. 1, 20, 15.04.2015.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Tnibar, A, Schougaard, H, Camitz, L, Rasmussen, J, Koene, M, Jahn, W & Markussen, B 2015, 'An international multi-centre prospective study on the efficacy of an intraarticular polyacrylamide hydrogel in horses with osteoarthritis: A 24months follow-up', Acta Veterinaria Scandinavica (Online), bind 57, nr. 1, 20. https://doi.org/10.1186/s13028-015-0110-6

APA

Tnibar, A., Schougaard, H., Camitz, L., Rasmussen, J., Koene, M., Jahn, W., & Markussen, B. (2015). An international multi-centre prospective study on the efficacy of an intraarticular polyacrylamide hydrogel in horses with osteoarthritis: A 24months follow-up. Acta Veterinaria Scandinavica (Online), 57(1), [20]. https://doi.org/10.1186/s13028-015-0110-6

Vancouver

Tnibar A, Schougaard H, Camitz L, Rasmussen J, Koene M, Jahn W o.a. An international multi-centre prospective study on the efficacy of an intraarticular polyacrylamide hydrogel in horses with osteoarthritis: A 24months follow-up. Acta Veterinaria Scandinavica (Online). 2015 apr. 15;57(1). 20. https://doi.org/10.1186/s13028-015-0110-6

Author

Tnibar, Aziz ; Schougaard, Hans ; Camitz, Linus ; Rasmussen, Jonas ; Koene, Marc ; Jahn, Werner ; Markussen, Bo. / An international multi-centre prospective study on the efficacy of an intraarticular polyacrylamide hydrogel in horses with osteoarthritis : A 24months follow-up. I: Acta Veterinaria Scandinavica (Online). 2015 ; Bind 57, Nr. 1.

Bibtex

@article{4de24214c04544d182cb267d3b0f98b3,
title = "An international multi-centre prospective study on the efficacy of an intraarticular polyacrylamide hydrogel in horses with osteoarthritis: A 24months follow-up",
abstract = "Background: Polyacrylamide hydrogel (PAAG) was evaluated recently to treat osteoarthritis (OA) in horses with highly encouraging results; however no long term field-study was done to explore its clinical efficacy and lasting effect. The objective of this study was to evaluate the efficacy of PAAG in improving clinical signs of OA in horses. We hypothesized that lameness grade would significantly improve and the effect would last at least 2years in osteoarthritic joints treated with PAAG. Forty three horses older than 2years with OA in only one joint based on clinical evaluation, intra-articular anaesthesia and imaging (radiography) were included in this study. Horses were injected with 2ml of PAAG into the affected joint and were followed up at 1, 3, 6, 12 and 24months. Efficacy of PAAG was evaluated by blinded clinical assessment of lameness. Adverse reactions to joint injection were assessed. Data relating to case details, type of activity, joint and limb involved, lameness duration, lameness grading, previous joint treatment, joint effusion grading, radiographic grading, and owner assessment were recorded. Factors associated with the outcome measure {"}lameness grading{"} were analyzed using generalized linear mixed model for logistic regression. Results: At 1, 3, 6, 12 and 24months follow-up, 59%, 69%, 79%, 81/% and 82.5% of horses were non-lame respectively. Reduction of joint effusion was observed over time. No side effect was observed in the treated joints. There was a significant decrease in lameness grade from baseline to 1, 3, 6, 12 and 24months (P",
keywords = "2years follow-up, Horse, Osteoarthritis, Polyacrylamide hydrogel, Treatment",
author = "Aziz Tnibar and Hans Schougaard and Linus Camitz and Jonas Rasmussen and Marc Koene and Werner Jahn and Bo Markussen",
year = "2015",
month = apr,
day = "15",
doi = "10.1186/s13028-015-0110-6",
language = "English",
volume = "57",
journal = "Acta Veterinaria Scandinavica",
issn = "0044-605X",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - An international multi-centre prospective study on the efficacy of an intraarticular polyacrylamide hydrogel in horses with osteoarthritis

T2 - A 24months follow-up

AU - Tnibar, Aziz

AU - Schougaard, Hans

AU - Camitz, Linus

AU - Rasmussen, Jonas

AU - Koene, Marc

AU - Jahn, Werner

AU - Markussen, Bo

PY - 2015/4/15

Y1 - 2015/4/15

N2 - Background: Polyacrylamide hydrogel (PAAG) was evaluated recently to treat osteoarthritis (OA) in horses with highly encouraging results; however no long term field-study was done to explore its clinical efficacy and lasting effect. The objective of this study was to evaluate the efficacy of PAAG in improving clinical signs of OA in horses. We hypothesized that lameness grade would significantly improve and the effect would last at least 2years in osteoarthritic joints treated with PAAG. Forty three horses older than 2years with OA in only one joint based on clinical evaluation, intra-articular anaesthesia and imaging (radiography) were included in this study. Horses were injected with 2ml of PAAG into the affected joint and were followed up at 1, 3, 6, 12 and 24months. Efficacy of PAAG was evaluated by blinded clinical assessment of lameness. Adverse reactions to joint injection were assessed. Data relating to case details, type of activity, joint and limb involved, lameness duration, lameness grading, previous joint treatment, joint effusion grading, radiographic grading, and owner assessment were recorded. Factors associated with the outcome measure "lameness grading" were analyzed using generalized linear mixed model for logistic regression. Results: At 1, 3, 6, 12 and 24months follow-up, 59%, 69%, 79%, 81/% and 82.5% of horses were non-lame respectively. Reduction of joint effusion was observed over time. No side effect was observed in the treated joints. There was a significant decrease in lameness grade from baseline to 1, 3, 6, 12 and 24months (P

AB - Background: Polyacrylamide hydrogel (PAAG) was evaluated recently to treat osteoarthritis (OA) in horses with highly encouraging results; however no long term field-study was done to explore its clinical efficacy and lasting effect. The objective of this study was to evaluate the efficacy of PAAG in improving clinical signs of OA in horses. We hypothesized that lameness grade would significantly improve and the effect would last at least 2years in osteoarthritic joints treated with PAAG. Forty three horses older than 2years with OA in only one joint based on clinical evaluation, intra-articular anaesthesia and imaging (radiography) were included in this study. Horses were injected with 2ml of PAAG into the affected joint and were followed up at 1, 3, 6, 12 and 24months. Efficacy of PAAG was evaluated by blinded clinical assessment of lameness. Adverse reactions to joint injection were assessed. Data relating to case details, type of activity, joint and limb involved, lameness duration, lameness grading, previous joint treatment, joint effusion grading, radiographic grading, and owner assessment were recorded. Factors associated with the outcome measure "lameness grading" were analyzed using generalized linear mixed model for logistic regression. Results: At 1, 3, 6, 12 and 24months follow-up, 59%, 69%, 79%, 81/% and 82.5% of horses were non-lame respectively. Reduction of joint effusion was observed over time. No side effect was observed in the treated joints. There was a significant decrease in lameness grade from baseline to 1, 3, 6, 12 and 24months (P

KW - 2years follow-up

KW - Horse

KW - Osteoarthritis

KW - Polyacrylamide hydrogel

KW - Treatment

U2 - 10.1186/s13028-015-0110-6

DO - 10.1186/s13028-015-0110-6

M3 - Journal article

C2 - 25887429

AN - SCOPUS:84939179935

VL - 57

JO - Acta Veterinaria Scandinavica

JF - Acta Veterinaria Scandinavica

SN - 0044-605X

IS - 1

M1 - 20

ER -

ID: 161368778